Home > Products > CD3 & CD74 > Recombinant Anti-CD3 x Anti-CD74 Bispecific Antibody (scFv-CH3)

Recombinant Anti-CD3 x Anti-CD74 Bispecific Antibody (scFv-CH3)  (BSFC-069)

Recombinant Anti-CD3 x Anti-CD74 Bispecific Antibody (scFv-CH3) contains two chains. The anti-CD3 scFv is fused to the Knob-CH3 domain via a hinge region and the same as the anti-CD74 scFv to the Hole-CH3 domain, or vice versa. The KIH CH3 domains can facilitate to form a heterodimer and this bivalent binding leads to improvement in avidity. This BsAb can retarget T cells to tumor cells. It is designed for the research of Multiple myeloma (MM) therapy.

Specifications
Targets
CD3 & CD74
Type
scFv-based Bispecific Fragments
Species Reactivity
Human
Target 1
CD3
Host Animal 1
Mouse
Target 2
CD74
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
Multiple myeloma (MM)
Targets
Target 1
CD3
Gene ID
UniProt ID
Alternative Names
CD3; CD3E; CD3e molecule; Cluster of differentiation 3; CD3e molecule, epsilon (CD3-TCR complex); T3E; TCRE; IMD18; T-cell surface glycoprotein CD3 epsilon chain; CD3-epsilon; T-cell surface antigen T3/Leu-4 epsilon chain; CD3e antigen, epsilon polypeptide (TiT3 complex); T-cell antigen receptor complex, epsilon subunit of T3
Target 2
CD74
Gene ID
UniProt ID
Alternative Names
CD74; Cluster of differentiation 74; CD74 molecule; CD74 antigen; CD74 molecule, major histocompatibility complex, class II invariant chain; II; DHLAG; HLADG; Ia-GAMMA; HLA class II histocompatibility antigen gamma chain; p33; HLA-DR-gamma; MHC HLA-DR gamma chain; Ia-associated invariant chain; gamma chain of class II antigens; HLA-DR antigens-associated invariant chain; CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)

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