Home > Products > CD3 & CD74 > Recombinant Anti-CD3 x Anti-CD74 Bispecific Antibody (scFv-Fc)

Recombinant Anti-CD3 x Anti-CD74 Bispecific Antibody (scFv-Fc)  (BSCFV-069)

Recombinant Anti-CD3 x Anti-CD74 Bispecific Antibody (scFv-Fc) is formed by fusing two different scFv fragments to the hinge and Fc regions, in which the Fc region are engineered by KIH. Two of scFv moiety has the antibody variable domain of either anti-CD3 specificity or anti-CD74 specificity, which produces bivalent IgG-like molecules with desired characteristics of intact antibodies. This BsAb can retarget T cells to tumor cells. It is designed for the research of Multiple myeloma (MM) therapy.

Datasheet
Specifications
Targets
CD3 & CD74
Type
scFv-based Bispecific Fragments
Species Reactivity
Human
Target 1
CD3
Host Animal 1
Mouse
Target 2
CD74
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
Multiple myeloma (MM)
Targets
Target 1
CD3
Gene ID
916
UniProt ID
P07766
Alternative Names
CD3; CD3E; CD3e molecule; Cluster of differentiation 3; CD3e molecule, epsilon (CD3-TCR complex); T3E; TCRE; IMD18; T-cell surface glycoprotein CD3 epsilon chain; CD3-epsilon; T-cell surface antigen T3/Leu-4 epsilon chain; CD3e antigen, epsilon polypeptide (TiT3 complex); T-cell antigen receptor complex, epsilon subunit of T3
Target 2
CD74
Gene ID
972
UniProt ID
P04233
Alternative Names
CD74; Cluster of differentiation 74; CD74 molecule; CD74 antigen; CD74 molecule, major histocompatibility complex, class II invariant chain; II; DHLAG; HLADG; Ia-GAMMA; HLA class II histocompatibility antigen gamma chain; p33; HLA-DR-gamma; MHC HLA-DR gamma chain; Ia-associated invariant chain; gamma chain of class II antigens; HLA-DR antigens-associated invariant chain; CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)

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