Recombinant Anti-CD3 x Anti-CD74 Bispecific Antibody (scFv-Fc) (BSCFV-069)

Recombinant Anti-CD3 x Anti-CD74 Bispecific Antibody (scFv-Fc) is formed by fusing two different scFv fragments to the hinge and Fc regions, in which the Fc region are engineered by KIH. Two of scFv moiety has the antibody variable domain of either anti-CD3 specificity or anti-CD74 specificity, which produces bivalent IgG-like molecules with desired characteristics of intact antibodies. This BsAb can retarget T cells to tumor cells. It is designed for the research of Multiple myeloma (MM) therapy.

Datasheet

Specifications

Targets

CD3 & CD74

Type

scFv-based Bispecific Fragments

Species Reactivity

Human

Target 1

CD3

Host Animal 1

Mouse

Target 2

CD74

Host Animal 2

Mouse

Application

FuncS; Promising therapeutic agent

Related Disease

Multiple myeloma (MM)

Targets

Target 1

CD3

Gene ID

916

UniProt ID

P07766

Alternative Names

CD3; CD3E; CD3e molecule; Cluster of differentiation 3; CD3e molecule, epsilon (CD3-TCR complex); T3E; TCRE; IMD18; T-cell surface glycoprotein CD3 epsilon chain; CD3-epsilon; T-cell surface antigen T3/Leu-4 epsilon chain; CD3e antigen, epsilon polypeptide (TiT3 complex); T-cell antigen receptor complex, epsilon subunit of T3

Target 2

CD74

Gene ID

972

UniProt ID

P04233

Alternative Names

CD74; Cluster of differentiation 74; CD74 molecule; CD74 antigen; CD74 molecule, major histocompatibility complex, class II invariant chain; II; DHLAG; HLADG; Ia-GAMMA; HLA class II histocompatibility antigen gamma chain; p33; HLA-DR-gamma; MHC HLA-DR gamma chain; Ia-associated invariant chain; gamma chain of class II antigens; HLA-DR antigens-associated invariant chain; CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)

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