Recombinant Anti-CD3 x Anti-CD74 Bispecific Antibody (VHH-Fc-VHH, Tetravalent HCAb) is a fusion protein of two diabodies connected together by an Fc region. In a diabody, the two VHHs with short linkers are from anti-CD3 and anti-CD74 antibodies. The VH and VL domains form an inter-chain pairing. The diabody with different specificities is fused to the Fc fragment, which results in 2+2 antigen-binding valency and exerts Fc-mediated functions or just extends the half-life. This BsAb can retarget T cells to tumor cells. It is designed for the research of Multiple myeloma (MM) therapy.
Constant Domain-extended Bispecific Fragments
FuncS; Promising therapeutic agent
Chronic lymphocytic leukemia (CLL); Non-Hodgkin's lymphoma (NHL); Diffuse large B cell lymphoma (DLBCL)
CD3; CD3E; CD3e molecule; Cluster of differentiation 3; CD3e molecule, epsilon (CD3-TCR complex); T3E; TCRE; IMD18; T-cell surface glycoprotein CD3 epsilon chain; CD3-epsilon; T-cell surface antigen T3/Leu-4 epsilon chain; CD3e antigen, epsilon polypeptide (TiT3 complex); T-cell antigen receptor complex, epsilon subunit of T3
CD79B; CD79b molecule, immunoglobulin-associated beta; Cluster of differentiation 79B; CD79b antigen; B29; IGB; AGM6; B-cell antigen receptor complex-associated protein beta chain; Ig-beta; B-cell-specific glycoprotein B29; immunoglobulin-associated B29 protein; CD79b antigen (immunoglobulin-associated beta); immunoglobulin-associated CD79 beta
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