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Recombinant Anti-CD3 x Anti-CD79B Bispecific Antibody (Fab-Fv)  (FABFV-070)

Recombinant Anti-CD3 x Anti-CD79B Bispecific Antibody (Fab-Fv) is designed to be expressed as two polypeptide chains. The heavy chain Fd fragment and light chain of an anti-CD3 antibody are fused with the VL and VH domains of an anti-CD79B antibody respectively. It can form natural in vivo heterodimerization. This BsAb can retarget T cells to tumor cells. It is designed for the research of Chronic lymphocytic leukemia (CLL); Non-Hodgkin's lymphoma (NHL); Diffuse large B cell lymphoma (DLBCL) therapy.

Specifications

Targets
CD3 & CD79B
Type
Fab-Fv
Species Reactivity
Human
Target 1
CD3
Host Animal 1
Mouse
Target 2
CD79B
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
Chronic lymphocytic leukemia (CLL); Non-Hodgkin's lymphoma (NHL); Diffuse large B cell lymphoma (DLBCL)

Targets

Target 1
CD3
Gene ID
UniProt ID
Alternative Names
CD3; CD3E; CD3e molecule; Cluster of differentiation 3; CD3e molecule, epsilon (CD3-TCR complex); T3E; TCRE; IMD18; T-cell surface glycoprotein CD3 epsilon chain; CD3-epsilon; T-cell surface antigen T3/Leu-4 epsilon chain; CD3e antigen, epsilon polypeptide (TiT3 complex); T-cell antigen receptor complex, epsilon subunit of T3
Target 2
CD79B
Gene ID
UniProt ID
Alternative Names
CD79B; CD79b molecule, immunoglobulin-associated beta; Cluster of differentiation 79B; CD79b antigen; B29; IGB; AGM6; B-cell antigen receptor complex-associated protein beta chain; Ig-beta; B-cell-specific glycoprotein B29; immunoglobulin-associated B29 protein; CD79b antigen (immunoglobulin-associated beta); immunoglobulin-associated CD79 beta

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