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Recombinant Anti-CD3 x Anti-CD79B Bispecific Antibody (scFv-Fc-scFv) (CAT#: BSTF-070)
Recombinant Anti-CD3 x Anti-CD79B Bispecific Antibody (scFv-Fc-scFv) is designed to be expressed as one chain, then assembled to a homodimer of bivalent scFv fragments and the Fc region of IgG. The anti-CD3 scFv is fused to the N-terminus of Fc via a hinge region while another anti-CD79B scFv is linked to the C-terminus of Fc. This scFv-Fc-scFv format has 2+2 antigen-binding valency by employing different scFv fragments. This BsAb can retarget T cells to tumor cells. It is designed for the research of Chronic lymphocytic leukemia (CLL); Non-Hodgkin's lymphoma (NHL); Diffuse large B cell lymphoma (DLBCL) therapy.
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