Recombinant Human Anti-CD3 x Human Anti-CD79B Bispecific Antibody (scFv4-Ig) (FVTIG-H246)

Recombinant Anti-CD3 x Anti-CD79B Bispecific Antibody (scFv4-Ig) is an appended IgG format, which includes four scFv moieties at the N-termini of the constant regions. It is a bivalent homodimer, in which one anti-CD3 scFv is fused to the CH1 domain of a heavy chain and another anti-CD79B scFv to the CL domain of a light chain, or vice versa. The resulting leads to 2+2 antigen-binding valency. This BsAb can retarget T cells to tumor cells. It is designed for the research of Chronic lymphocytic leukemia (CLL); Non-Hodgkin's lymphoma (NHL); Diffuse large B cell lymphoma (DLBCL) therapy.

Datasheet INQUIRY

Specifications

Targets

CD3 & CD79B

Type

Appended IgGs

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Chronic lymphocytic leukemia (CLL); Non-Hodgkin's lymphoma (NHL); Diffuse large B cell lymphoma (DLBCL)

Targets

Target 1

CD3

Gene ID

916

UniProt ID

P07766

Alternative Names

CD3; CD3E; CD3e molecule; Cluster of differentiation 3; CD3e molecule, epsilon (CD3-TCR complex); T3E; TCRE; IMD18; T-cell surface glycoprotein CD3 epsilon chain; CD3-epsilon; T-cell surface antigen T3/Leu-4 epsilon chain; CD3e antigen, epsilon polypeptide (TiT3 complex); T-cell antigen receptor complex, epsilon subunit of T3

Target 2

CD79B

Gene ID

974

UniProt ID

P40259

Alternative Names

CD79B; CD79b molecule, immunoglobulin-associated beta; Cluster of differentiation 79B; CD79b antigen; B29; IGB; AGM6; B-cell antigen receptor complex-associated protein beta chain; Ig-beta; B-cell-specific glycoprotein B29; immunoglobulin-associated B29 protein; CD79b antigen (immunoglobulin-associated beta); immunoglobulin-associated CD79 beta

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Human Anti-CD3 x Human Anti-CD79B Bispecific Antibody (scFv4-Ig) (CAT#: FVTIG-H246)

Specifications

Targets

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