Home > Products > CD3 & CD79B > Recombinant Anti-CD3 x Anti-CD79B Bispecific Antibody (VHH-Fc-VHH)

Recombinant Anti-CD3 x Anti-CD79B Bispecific Antibody (VHH-Fc-VHH)  (HCAB-016)

Recombinant Anti-CD3 x Anti-CD79B Bispecific Antibody (VHH-Fc-VHH, Tetravalent HCAb) is a fusion protein of two diabodies connected together by an Fc region. In a diabody, the two VHHs with short linkers are from anti-CD3 and anti-CD79B antibodies. The VH and VL domains form an inter-chain pairing. The diabody with different specificities is fused to the Fc fragment, which results in 2+2 antigen-binding valency and exerts Fc-mediated functions or just extends the half-life. This BsAb can retarget T cells to tumor cells. It is designed for the research of Chronic lymphocytic leukemia (CLL); Non-Hodgkin's lymphoma (NHL); Diffuse large B cell lymphoma (DLBCL) therapy.

Specifications

Targets
CD3 & CD79B
Type
Constant Domain-extended Bispecific Fragments
Species Reactivity
Human
Target 1
CD3
Host Animal 1
llama
Target 2
CD79B
Host Animal 2
llama
Application
FuncS; Promising therapeutic agent
Related Disease
HIV-1 infection, AIDS

Targets

Target 1
CD3
Gene ID
UniProt ID
Alternative Names
CD3; CD3E; CD3e molecule; Cluster of differentiation 3; CD3e molecule, epsilon (CD3-TCR complex); T3E; TCRE; IMD18; T-cell surface glycoprotein CD3 epsilon chain; CD3-epsilon; T-cell surface antigen T3/Leu-4 epsilon chain; CD3e antigen, epsilon polypeptide (TiT3 complex); T-cell antigen receptor complex, epsilon subunit of T3
Target 2
CD79B
Gene ID
UniProt ID
Alternative Names
CD8A; CD8a molecule; Cluster of differentiation 8; CD8; MAL; p32; Leu2

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