Recombinant Human Anti-CD3 x Human Anti-CLEC12A Bispecific Antibody (Fab-scFv-Fc) (FABVC-H249)

Recombinant Anti-CD3 x Anti-CLEC12A Bispecific Antibody (Fab-scFv-Fc) requires expression of three polypeptide chains, encoding two heavy chains (Fc-containing chains) and one light chain, respectively. The Fab of anti-CD3 antibody variable domain is fused to the Fc-knob domain with a hinge region and the same as the scFv of anti-CLEC12A to the Fc-hole domain, or vice versa. The Fab-Fc and scFv-Fc fragments can be paired via the interaction of the Fc regions. This BsAb can retarget T cells to tumor cells. It is designed for the research of Acute myeloid leukemia (AML); Myelodysplastic syndromes (MDS); Chronic myelogenous leukemia (CML) therapy.

Datasheet INQUIRY

Specifications

Targets

CD3 & CLEC12A

Type

Fab-Fc Fusion Proteins

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Acute myeloid leukemia (AML); Myelodysplastic syndromes (MDS); Chronic myelogenous leukemia (CML)

Targets

Target 1

CD3

Gene ID

916

UniProt ID

P07766

Alternative Names

CD3; CD3E; CD3e molecule; Cluster of differentiation 3; CD3e molecule, epsilon (CD3-TCR complex); T3E; TCRE; IMD18; T-cell surface glycoprotein CD3 epsilon chain; CD3-epsilon; T-cell surface antigen T3/Leu-4 epsilon chain; CD3e antigen, epsilon polypeptide (TiT3 complex); T-cell antigen receptor complex, epsilon subunit of T3

Target 2

CLEC12A

Gene ID

160364

UniProt ID

Q5QGZ9

Alternative Names

CLEC12A; C-type lectin domain family 12, member A; CLL1; MICL; CLL-1; DCAL-2; C-type lectin domain family 12 member A; C-type lectin protein CLL-1; C-type lectin-like molecule-1; dendritic cell-associated lectin 2; myeloid inhibitory C-type lectin-like receptor

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Human Anti-CD3 x Human Anti-CLEC12A Bispecific Antibody (Fab-scFv-Fc) (CAT#: FABVC-H249)

Specifications

Targets

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