Recombinant Anti-CD3 x Anti-CLEC12A Bispecific Antibody (Tandem scFv) (BSFV-073)

Recombinant Anti-CD3 x Anti-CLEC12A Bispecific Antibody (Tandem scFv) is designed to be expressed as a scFv from an anti-CD3 antibody variable domains fused with a scFv from an anti-CLEC12A antibody variable domains. It contains a His-tag at the C/N terminus for affinity purification. The BsAb exits as monomer in reducing and non-reducing conditions. This BsAb can retarget T cells to tumor cells. It is designed for the research of Acute myeloid leukemia (AML); Myelodysplastic syndromes (MDS); Chronic myelogenous leukemia (CML) therapy.

Datasheet INQUIRY

Specifications

Targets

CD3 & CLEC12A

Type

Tandem scFv

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Acute myeloid leukemia (AML); Myelodysplastic syndromes (MDS); Chronic myelogenous leukemia (CML)

Targets

Target 1

CD3

Gene ID

916

UniProt ID

P07766

Alternative Names

CD3; CD3E; CD3e molecule; Cluster of differentiation 3; CD3e molecule, epsilon (CD3-TCR complex); T3E; TCRE; IMD18; T-cell surface glycoprotein CD3 epsilon chain; CD3-epsilon; T-cell surface antigen T3/Leu-4 epsilon chain; CD3e antigen, epsilon polypeptide (TiT3 complex); T-cell antigen receptor complex, epsilon subunit of T3

Target 2

CLEC12A

Gene ID

160364

UniProt ID

Q5QGZ9

Alternative Names

CLEC12A; C-type lectin domain family 12, member A; CLL1; MICL; CLL-1; DCAL-2; C-type lectin domain family 12 member A; C-type lectin protein CLL-1; C-type lectin-like molecule-1; dendritic cell-associated lectin 2; myeloid inhibitory C-type lectin-like receptor

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Anti-CD3 x Anti-CLEC12A Bispecific Antibody (Tandem scFv) (CAT#: BSFV-073)

Specifications

Targets

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