Recombinant Human Anti-CD3 x Human Anti-CSPG4 Bispecific Antibody (scFv4-Ig) (FVTIG-H270)

Recombinant Anti-CD3 x Anti-CSPG4 Bispecific Antibody (scFv4-Ig) is an appended IgG format, which includes four scFv moieties at the N-termini of the constant regions. It is a bivalent homodimer, in which one anti-CD3 scFv is fused to the CH1 domain of a heavy chain and another anti-CSPG4 scFv to the CL domain of a light chain, or vice versa. The resulting leads to 2+2 antigen-binding valency. This BsAb can retarget T cells to tumor cells. It is designed for the research of Melanoma therapy.

Datasheet INQUIRY

Specifications

Targets

CD3 & CSPG4

Type

Appended IgGs

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Melanoma

Targets

Target 1

CD3

Gene ID

916

UniProt ID

P07766

Alternative Names

CD3; CD3E; CD3e molecule; Cluster of differentiation 3; CD3e molecule, epsilon (CD3-TCR complex); T3E; TCRE; IMD18; T-cell surface glycoprotein CD3 epsilon chain; CD3-epsilon; T-cell surface antigen T3/Leu-4 epsilon chain; CD3e antigen, epsilon polypeptide (TiT3 complex); T-cell antigen receptor complex, epsilon subunit of T3

Target 2

CSPG4

Gene ID

1464

UniProt ID

Q6UVK1

Alternative Names

NG2; MCSP; MCSPG; MSK16; HMW-MAA; MEL-CSPG; Melanoma-associated chondroitin sulfate proteoglycan; CSPG4; Chondroitin sulfate proteoglycan 4; Neuron-glial antigen 2; gp240

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Human Anti-CD3 x Human Anti-CSPG4 Bispecific Antibody (scFv4-Ig) (CAT#: FVTIG-H270)

Specifications

Targets

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