Home > Products > CD3 & CXCR5 > Recombinant Anti-CD3 x Anti-CXCR5 Bispecific Antibody (scFv-CH3)

Recombinant Anti-CD3 x Anti-CXCR5 Bispecific Antibody (scFv-CH3)  (BSFC-075)

Recombinant Anti-CD3 x Anti-CXCR5 Bispecific Antibody (scFv-CH3) contains two chains. The anti-CD3 scFv is fused to the Knob-CH3 domain via a hinge region and the same as the anti-CXCR5 scFv to the Hole-CH3 domain, or vice versa. The KIH CH3 domains can facilitate to form a heterodimer and this bivalent binding leads to improvement in avidity. This BsAb can retarget T cells to tumor cells. It is designed for the research of Non-Hodgkin's lymphoma (NHL) therapy.

Specifications
Targets
CD3 & CXCR5
Type
scFv-based Bispecific Fragments
Species Reactivity
Human
Target 1
CD3
Host Animal 1
Mouse
Target 2
CXCR5
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
Non-Hodgkin's lymphoma (NHL)
Targets
Target 1
CD3
Gene ID
UniProt ID
Alternative Names
CD3; CD3E; CD3e molecule; Cluster of differentiation 3; CD3e molecule, epsilon (CD3-TCR complex); T3E; TCRE; IMD18; T-cell surface glycoprotein CD3 epsilon chain; CD3-epsilon; T-cell surface antigen T3/Leu-4 epsilon chain; CD3e antigen, epsilon polypeptide (TiT3 complex); T-cell antigen receptor complex, epsilon subunit of T3
Target 2
CXCR5
Gene ID
UniProt ID
Alternative Names
CXCR5; chemokine (C-X-C motif) receptor 5; BLR1; CD185; MDR15; C-X-C chemokine receptor type 5; CXC-R5; CXCR-5; MDR-15; monocyte-derived receptor 15; Burkitt lymphoma receptor 1, GTP-binding protein; Burkitt lymphoma receptor 1, GTP binding protein (chemokine (C-X-C motif) receptor 5)
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