Home > Products > CD3 & FcRH5 > Recombinant Anti-CD3 x Anti-FcRH5 Bispecific Antibody (scFv-CH1/CL)

Recombinant Anti-CD3 x Anti-FcRH5 Bispecific Antibody (scFv-CH1/CL)  (BSCC-H257)

Recombinant Anti-CD3 x Anti-FcRH5 Bispecific Antibody (scFv-CH1/CL) is designed to be expressed as two chains. One scFv from an anti-CD3 antibody variable domain is fused to CH1 and the other scFv from an anti-FcRH5 antibody variable domain fused to CL, or vice versa. And the CH1 and CL domains are linked covalently via a natural disulfide bond. This BsAb can retarget T cells to tumor cells. It is designed for the research of Multiple myeloma (MM); B cell malignancies therapy.

Specifications
Targets
CD3 & FcRH5
Type
scFv-based Bispecific Fragments
Species Reactivity
Human
Target 1
CD3
Host Animal 1
Mouse
Target 2
FcRH5
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
Multiple myeloma (MM); B cell malignancies
Targets
Target 1
CD3
Gene ID
UniProt ID
Alternative Names
CD3; CD3E; CD3e molecule; Cluster of differentiation 3; CD3e molecule, epsilon (CD3-TCR complex); T3E; TCRE; IMD18; T-cell surface glycoprotein CD3 epsilon chain; CD3-epsilon; T-cell surface antigen T3/Leu-4 epsilon chain; CD3e antigen, epsilon polypeptide (TiT3 complex); T-cell antigen receptor complex, epsilon subunit of T3
Target 2
FcRH5
Gene ID
UniProt ID
Alternative Names
FCRL5; Fc receptor like 5; CD307; FCRH5; IRTA2; BXMAS1; CD307e; PRO820

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