Home > Products > CD3 & gpA33 > Recombinant Anti-CD3 x Anti-gpA33 Bispecific Antibody (Diabody-Fc)

Recombinant Anti-CD3 x Anti-gpA33 Bispecific Antibody (Diabody-Fc)  (BSDBF-086)

Recombinant Anti-CD3 x Anti-gpA33 Bispecific Antibody (Diabody-Fc) is a fusion protein of two diabodies connected together by an Fc region. In a diabody, the two scFvs with short linkers are from anti-CD3 and anti-gpA33 antibodies. The VH and VL domains form an inter-chain pairing. The diabody with different specificities is fused to the Fc fragment, which results in 2+2 antigen-binding valency and exerts Fc-mediated functions or just extends the half-life. This BsAb can retarget T cells to tumor cells. It is designed for the research of Non-Hodgkin's lymphoma (NHL) therapy.

Specifications
Targets
CD3 & gpA33
Type
Constant Domain-extended Bispecific Fragments
Species Reactivity
Human
Target 1
CD3
Host Animal 1
Mouse
Target 2
gpA33
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
Non-Hodgkin's lymphoma (NHL)
Targets
Target 1
CD3
Gene ID
UniProt ID
Alternative Names
CD3; CD3E; CD3e molecule; Cluster of differentiation 3; CD3e molecule, epsilon (CD3-TCR complex); T3E; TCRE; IMD18; T-cell surface glycoprotein CD3 epsilon chain; CD3-epsilon; T-cell surface antigen T3/Leu-4 epsilon chain; CD3e antigen, epsilon polypeptide (TiT3 complex); T-cell antigen receptor complex, epsilon subunit of T3
Target 2
gpA33
Gene ID
UniProt ID
Alternative Names
GPA33; glycoprotein A33; glycoprotein A33 (transmembrane); A33; cell surface A33 antigen; transmembrane glycoprotein A33

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