Home > Products > CD3 & GPC3 > Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (F(ab')2-scFv2)

Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (F(ab')2-scFv2)  (BABFV-H263)

Recombinant Anti-CD3 x Anti-GPC3 Bispecific Antibody (F(ab')2-scFv2) is designed to be expressed as two chains combined via a hinge region. The scFv of the anti-CD3 specificity is fused to the C terminus of the anti-GPC3 Fab fragment, or vice versa. This format comprises four binding sites (two same scFv regions and two same Fab fragments), two for each antigen. This BsAb can retarget T cells to tumor cells. It is designed for the research of Hepatocellular cancer (HCC); Melanoma therapy.

Specifications
Targets
CD3 & GPC3
Type
Fab-Fc Fusion Proteins
Species Reactivity
Human
Target 1
CD3
Host Animal 1
Human
Target 2
GPC3
Host Animal 2
Human
Application
FuncS; Promising therapeutic agent
Related Disease
Hepatocellular cancer (HCC); Melanoma
Targets
Target 1
CD3
Gene ID
UniProt ID
Alternative Names
CD3; CD3E; CD3e molecule; Cluster of differentiation 3; CD3e molecule, epsilon (CD3-TCR complex); T3E; TCRE; IMD18; T-cell surface glycoprotein CD3 epsilon chain; CD3-epsilon; T-cell surface antigen T3/Leu-4 epsilon chain; CD3e antigen, epsilon polypeptide (TiT3 complex); T-cell antigen receptor complex, epsilon subunit of T3
Target 2
GPC3
Gene ID
UniProt ID
Alternative Names
SGB; DGSX; MXR7; SDYS; SGBS; OCI-5; SGBS1; GTR2-2; GPC3; glypican 3

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