Recombinant Anti-CD3 VHH x Anti-GPNMB VHH BispecificAntibody (Bi-nanobody) (BIVHH-027)

Recombinant Anti-CD3 x Anti-GPNMB Bispecific Antibody (Bi-nanobody) is designed to be expressed as a VHH from anti-CD3 antibody variable domains fused with a VHH from an anti-GPNMB antibody variable domains. It contains a His-tag at the C/N terminus for affinity purification. The BsAb exits as monomer in reducing and non-reducing conditions. This BsAb can retarget T cells to tumor cells. It is designed for the research of Melanoma; Breast cancer therapy.

Datasheet

Specifications

Targets

CD3 & GPNMB

Type

Bi-nanobody

Species Reactivity

Human

Target 1

CD3

Host Animal 1

llama

Target 2

GPNMB

Host Animal 2

llama

Application

FuncS; Promising therapeutic agent

Related Disease

Melanoma; Breast cancer

Targets

Target 1

CD3

Gene ID

916

UniProt ID

P07766

Alternative Names

CD3; CD3E; CD3e molecule; Cluster of differentiation 3; CD3e molecule, epsilon (CD3-TCR complex); T3E; TCRE; IMD18; T-cell surface glycoprotein CD3 epsilon chain; CD3-epsilon; T-cell surface antigen T3/Leu-4 epsilon chain; CD3e antigen, epsilon polypeptide (TiT3 complex); T-cell antigen receptor complex, epsilon subunit of T3

Target 2

GPNMB

Gene ID

93695

UniProt ID

Q99P91

Alternative Names

GPNMB; glycoprotein (transmembrane) nmb; ipd; Dchil; DC-HIL; transmembrane glycoprotein NMB; osteoactivin; iris pigment dispersion; dendritic cell-associated transmembrane protein; dendritic cell-associated heparin sulfate proteoglycan-dependent integrin ligand; Glycoprotein non-metastatic b

Our services and products are only for lab research, not for any diagnostic or therapeutic use.

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USA
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-381-2994
Fax: 1-631-207-8356
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UK
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Tel: 44-207-097-1828
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