Home > Products > CD3 & GPNMB > Recombinant Anti-CD3 x Anti-GPNMB Bispecific Antibody (scFv4-Ig)

Recombinant Anti-CD3 x Anti-GPNMB Bispecific Antibody (scFv4-Ig)  (FVTIG-088)

Recombinant Anti-CD3 x Anti-GPNMB Bispecific Antibody (scFv4-Ig) is an appended IgG format, which includes four scFv moieties at the N-termini of the constant regions. It is a bivalent homodimer, in which one anti-CD3 scFv is fused to the CH1 domain of a heavy chain and another anti-GPNMB scFv to the CL domain of a light chain, or vice versa. The resulting leads to 2+2 antigen-binding valency. This BsAb can retarget T cells to tumor cells. It is designed for the research of Melanoma; Breast cancer therapy.

Specifications
Targets
CD3 & GPNMB
Type
Appended IgGs
Species Reactivity
Human
Target 1
CD3
Host Animal 1
Mouse
Target 2
GPNMB
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
Melanoma; Breast cancer
Targets
Target 1
CD3
Gene ID
UniProt ID
Alternative Names
CD3; CD3E; CD3e molecule; Cluster of differentiation 3; CD3e molecule, epsilon (CD3-TCR complex); T3E; TCRE; IMD18; T-cell surface glycoprotein CD3 epsilon chain; CD3-epsilon; T-cell surface antigen T3/Leu-4 epsilon chain; CD3e antigen, epsilon polypeptide (TiT3 complex); T-cell antigen receptor complex, epsilon subunit of T3
Target 2
GPNMB
Gene ID
UniProt ID
Alternative Names
GPNMB; glycoprotein (transmembrane) nmb; ipd; Dchil; DC-HIL; transmembrane glycoprotein NMB; osteoactivin; iris pigment dispersion; dendritic cell-associated transmembrane protein; dendritic cell-associated heparin sulfate proteoglycan-dependent integrin ligand; Glycoprotein non-metastatic b

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