Recombinant Anti-CD3 x Anti-GPNMB Bispecific Antibody (Single-chain Diabody) (SCDB-088)

Recombinant Anti-CD3 x Anti-GPNMB Bispecific Antibody (Single-chain Diabody) is designed to be expressed as one polypeptide chain with four variable domains from two parental antibodies. The middle linker is long enough to form scFv dimers between the two diabody chains. This BsAb can retarget T cells to tumor cells. It is designed for the research of Melanoma; Breast cancer therapy.

Datasheet

Specifications

Targets

CD3 & GPNMB

Type

Single-chain Diabody

Species Reactivity

Human

Target 1

CD3

Host Animal 1

Mouse

Target 2

GPNMB

Host Animal 2

Mouse

Application

FuncS; Promising therapeutic agent

Related Disease

Melanoma; Breast cancer

Targets

Target 1

CD3

Gene ID

916

UniProt ID

P07766

Alternative Names

CD3; CD3E; CD3e molecule; Cluster of differentiation 3; CD3e molecule, epsilon (CD3-TCR complex); T3E; TCRE; IMD18; T-cell surface glycoprotein CD3 epsilon chain; CD3-epsilon; T-cell surface antigen T3/Leu-4 epsilon chain; CD3e antigen, epsilon polypeptide (TiT3 complex); T-cell antigen receptor complex, epsilon subunit of T3

Target 2

GPNMB

Gene ID

93695

UniProt ID

Q99P91

Alternative Names

GPNMB; glycoprotein (transmembrane) nmb; ipd; Dchil; DC-HIL; transmembrane glycoprotein NMB; osteoactivin; iris pigment dispersion; dendritic cell-associated transmembrane protein; dendritic cell-associated heparin sulfate proteoglycan-dependent integrin ligand; Glycoprotein non-metastatic b

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