Home > Products > CD3 & HIV-1 gp120 > Recombinant Anti-CD3 x Anti-HIV-1 gp120 Bispecific Antibody (Diabody-CH3)

Recombinant Anti-CD3 x Anti-HIV-1 gp120 Bispecific Antibody (Diabody-CH3)  (BSDBC-H260)

Recombinant Anti-CD3 x Anti-HIV-1 gp120 Bispecific Antibody (Diabody-CH3) is a fusion protein of two diabodies connected together by a CH3 region. In a diabody, the two scFvs with short linkers are from anti-CD3 and anti-HIV-1 gp120 antibodies. The VH and VL domains form an inter-chain pairing. The diabody with different specificities is fused to each of the CH3 chains, which results in 2+2 antigen-binding valency and extends the half-life of this BsAb. This BsAb can retarget T cells to HIV-1 infected cells. It is designed for the research of HIV-1 infection, AIDS therapy.

Specifications
Targets
CD3 & HIV-1 gp120
Type
Constant Domain-extended Bispecific Fragments
Species Reactivity
Human
Target 1
CD3
Host Animal 1
Human
Target 2
HIV-1 gp120
Host Animal 2
Human
Application
FuncS; Promising therapeutic agent
Related Disease
HIV-1 infection, AIDS
Targets
Target 1
CD3
Gene ID
UniProt ID
Alternative Names
CD3; CD3E; CD3e molecule; Cluster of differentiation 3; CD3e molecule, epsilon (CD3-TCR complex); T3E; TCRE; IMD18; T-cell surface glycoprotein CD3 epsilon chain; CD3-epsilon; T-cell surface antigen T3/Leu-4 epsilon chain; CD3e antigen, epsilon polypeptide (TiT3 complex); T-cell antigen receptor complex, epsilon subunit of T3
Target 2
HIV-1 gp120
Gene ID
UniProt ID
Alternative Names
ENV; gp160; Envelope glycoprotein 120; envelope glycoprotein; Envelope surface glycoprotein gp160, precursor; hypothetical protein; Envelope surface glycoprotein gp120; Envelope transmembrane domain; human immunodeficiency virus type 1; human immunodeficiency virus type 1 gp120; human immunodeficiency virus type 1 glycoprotein 120; gp41; GP41; glycoprotein 41

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