Recombinant Anti-CD3 x Anti-HIV-1 gp120 Bispecific Antibody (Fab-VHH-Fc) requires expression of three polypeptide chains, encoding two heavy chains (Fc-containing chains) and one light chain, respectively. The Fab of anti-CD3 antibody variable domain is fused to the Fc-knob domain with a hinge region and the same as the VHH of anti-HIV-1 gp120 to the Fc-hole domain, or vice versa. The Fab-Fc and VHH-Fc fragments can be paired via the interaction of the Fc regions. This BsAb can retarget T cells to HIV-1 infected cells. It is designed for the research of HIV-1 infection, AIDS therapy.
Fab-Fc Fusion Proteins
FuncS; Promising therapeutic agent
HIV-1 infection, AIDS
CD3; CD3E; CD3e molecule; Cluster of differentiation 3; CD3e molecule, epsilon (CD3-TCR complex); T3E; TCRE; IMD18; T-cell surface glycoprotein CD3 epsilon chain; CD3-epsilon; T-cell surface antigen T3/Leu-4 epsilon chain; CD3e antigen, epsilon polypeptide (TiT3 complex); T-cell antigen receptor complex, epsilon subunit of T3
ENV; gp160; Envelope glycoprotein 120; envelope glycoprotein; Envelope surface glycoprotein gp160, precursor; hypothetical protein; Envelope surface glycoprotein gp120; Envelope transmembrane domain; human immunodeficiency virus type 1; human immunodeficiency virus type 1 gp120; human immunodeficiency virus type 1 glycoprotein 120; gp41; GP41; glycoprotein 41
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