Home > Products > CD3 & HIV-1 gp120 > Recombinant Anti-CD3 x Anti-HIV-1 gp120 Bispecific Antibody (scFv-IgG)

Recombinant Anti-CD3 x Anti-HIV-1 gp120 Bispecific Antibody (scFv-IgG)  (BSSG-084)

Recombinant Anti-CD3 x Anti-HIV-1 gp120 Bispecific Antibody (scFv-IgG) is formed by an IgG and two scFv fragments. The scFvs from an anti-CD3 antibody variable domain are respectively connected to the N terminus of the anti-HIV-1 gp120 IgG heavy chains or light chains to form scFv-(H)IgG or scFv-(L)IgG. It is a type of appended IgGs and has 2+2 antigen-binding valency. This BsAb can retarget T cells to HIV-1 infected cells. It is designed for the research of HIV-1 infection, AIDS therapy.

Datasheet
Specifications
Targets
CD3 & HIV-1 gp120
Type
Appended IgGs
Species Reactivity
Human
Target 1
CD3
Host Animal 1
Mouse
Target 2
HIV-1 gp120
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
HIV-1 infection, AIDS
Targets
Target 1
CD3
Gene ID
916
UniProt ID
P07766
Alternative Names
CD3; CD3E; CD3e molecule; Cluster of differentiation 3; CD3e molecule, epsilon (CD3-TCR complex); T3E; TCRE; IMD18; T-cell surface glycoprotein CD3 epsilon chain; CD3-epsilon; T-cell surface antigen T3/Leu-4 epsilon chain; CD3e antigen, epsilon polypeptide (TiT3 complex); T-cell antigen receptor complex, epsilon subunit of T3
Target 2
HIV-1 gp120
Gene ID
155971
UniProt ID
Q0H5Z9
Alternative Names
ENV; gp160; Envelope glycoprotein 120; envelope glycoprotein; Envelope surface glycoprotein gp160, precursor; hypothetical protein; Envelope surface glycoprotein gp120; Envelope transmembrane domain; human immunodeficiency virus type 1; human immunodeficiency virus type 1 gp120; human immunodeficiency virus type 1 glycoprotein 120; gp41; GP41; glycoprotein 41
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