Home > Products > CD3 & IGF1R > Recombinant Human Anti-CD3 x Human Anti-IGF1R Bispecific Antibody (scDiabody-Fc)

Recombinant Human Anti-CD3 x Human Anti-IGF1R Bispecific Antibody (scDiabody-Fc)  (SCDBF-H268)

Recombinant Anti-CD3 x Anti-IGF1R Bispecific Antibody (scDiabody-Fc) is a fusion protein of two scDiabodies with an Fc region. In single-chain Diabodies, an additional connecting linker is introduced between chains of the anti-CD3/anti-IGF1R diabody. The scDiabody with two specificities is further fused to the Fc domain to form BsAb with 2+2 antigen-binding valency. This BsAb can retarget T cells to tumor cells. It is designed for the research of Melanoma; Colon cancer; Pancreas cancer; Prostate cancer; Kidney cancer therapy.

Specifications

Targets
CD3 & IGF1R
Type
Constant Domain-extended Bispecific Fragments
Species Reactivity
Human
Target 1
CD3
Host Animal 1
Human
Target 2
IGF1R
Host Animal 2
Human
Application
FuncS; Promising therapeutic agent
Related Disease
Melanoma; Colon cancer; Pancreas cancer; Prostate cancer; Kidney cancer

Targets

Target 1
CD3
Gene ID
UniProt ID
Alternative Names
CD3; CD3E; CD3e molecule; Cluster of differentiation 3; CD3e molecule, epsilon (CD3-TCR complex); T3E; TCRE; IMD18; T-cell surface glycoprotein CD3 epsilon chain; CD3-epsilon; T-cell surface antigen T3/Leu-4 epsilon chain; CD3e antigen, epsilon polypeptide (TiT3 complex); T-cell antigen receptor complex, epsilon subunit of T3
Target 2
IGF1R
Gene ID
UniProt ID
Alternative Names
IGF1R; insulin-like growth factor 1 receptor; IGFR; CD221; IGFIR; JTK13; IGF-I receptor; soluble IGF1R variant 1; soluble IGF1R variant 2; insulin-like growth factor I receptor

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