Name: Recombinant Anti-CD3 x Anti-MUC1 Bispecific Antibody (sdAb-Fc-sdAb)
SKU: HCAB-030
Rating: 5 (1 reviews)

Recombinant Anti-CD3 x Anti-MUC1 Bispecific Antibody (sdAb-Fc-sdAb, Tetravalent Heavy Chain-only Antibody, Tetravalent HCAb) is symmetric protein with two pairs of single domain antibodies (sdAb), from anti-CD3 and anti-MUC1 antibodies, fused to the N-terminus and C-terminus of the Fc separately. This BsAb is bispecific, tetravelant, 2+2 antigen-binding valency. It can retarget T cells to tumor cells. It is designed for the research of Pancreatic cancer; Ovarian cancer; Breast cancer; Bile duct cancer (BDC) therapy.

Datasheet INQUIRY

Specifications

Targets

CD3 & MUC1

Type

sdAb-Fc-sdAb

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Pancreatic cancer; Ovarian cancer; Breast cancer; Bile duct cancer (BDC)

Host Animal 1

llama

Host Animal 2

llama

Targets

Target 1

CD3

Gene ID

916

UniProt ID

P07766

Alternative Names

CD3 (Cluster of differentiation 3), originally known as T3, is one of the first groups of human T lymphocyte surface antigens recognized by monoclonal antibodies. It has been reported that antibodies against CD3 could either stimulate T cells to divide or inhibit the progress of effector functions according to the conditions used. It plays an important role in T cell and the CD3 T-cell co-receptor helps to activate the cytotoxic T-Cell and T helper cells. The CD3 molecule is composed of a protein complex and consists of four distinct chains. The complex of mammals contains a CD3γ chain, a CD3δ chain, and two CD3ε chains. All these chains associate with T-cell receptor and the ζ-chain to generate an activation signal in T lymphocytes.

Target 2

MUC1

Gene ID

5133

UniProt ID

Q15116

Alternative Names

PDCD1; programmed cell death 1; PD1; PD-1; CD279; SLEB2; hPD-1; hPD-l; hSLE1; programmed cell death protein 1; protein PD-1; systemic lupus erythematosus susceptibility 2

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Anti-CD3 x Anti-MUC1 Bispecific Antibody (sdAb-Fc-sdAb) (CAT#: HCAB-030)

Specifications

Targets

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