Home > Products > CD3 & PD1 > Recombinant Anti-CD3 VHH x Anti-PD1 VHH BispecificAntibody (Bi-sdAb)

Recombinant Anti-CD3 VHH x Anti-PD1 VHH BispecificAntibody (Bi-sdAb)  (BIVHH-031)

Recombinant Anti-CD3 x Anti-PD1 Bispecific Antibody (Bi-sdAb) is designed to be expressed as a VHH from anti-CD3 antibody variable domains fused with a VHH from an anti-PD1 antibody variable domains. It contains a His-tag at the C/N terminus for affinity purification. The BsAb exits as monomer in reducing and non-reducing conditions. This BsAb can retarget T cells to tumor cells. It is designed for the research of Esophageal cancer; Hodgkin lymphoma; Renal cell cancer (RCC); Mesothelioma; Head and neck squamous cell cancer (HNSCC); Anal cancer; Gastric cancer; Hepatocellular cancer; Nasopharyngeal cancer; Non-small cell lung cancer (NSCLC); Solid tumors therapy.

Specifications

Targets
CD3 & PD1
Type
Bi-sdAb
Species Reactivity
Human
Target 1
CD3
Host Animal 1
llama
Target 2
PD1
Host Animal 2
llama
Application
FuncS; Promising therapeutic agent
Related Disease
Esophageal cancer; Hodgkin lymphoma; Renal cell cancer (RCC); Mesothelioma; Head and neck squamous cell cancer (HNSCC); Anal cancer; Gastric cancer; Hepatocellular cancer; Nasopharyngeal cancer; Non-small cell lung cancer (NSCLC); Solid tumors

Targets

Target 1
CD3
Gene ID
UniProt ID
Alternative Names
CD3 (Cluster of differentiation 3), originally known as T3, is one of the first groups of human T lymphocyte surface antigens recognized by monoclonal antibodies. It has been reported that antibodies against CD3 could either stimulate T cells to divide or inhibit the progress of effector functions according to the conditions used. It plays an important role in T cell and the CD3 T-cell co-receptor helps to activate the cytotoxic T-Cell and T helper cells. The CD3 molecule is composed of a protein complex and consists of four distinct chains. The complex of mammals contains a CD3γ chain, a CD3δ chain, and two CD3ε chains. All these chains associate with T-cell receptor and the ζ-chain to generate an activation signal in T lymphocytes.
Target 2
PD1
Gene ID
UniProt ID
Alternative Names
PDCD1; programmed cell death 1; PD1; PD-1; CD279; SLEB2; hPD-1; hPD-l; hSLE1; programmed cell death protein 1; protein PD-1; systemic lupus erythematosus susceptibility 2

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