Recombinant Anti-CD3 VHH x Anti-PSMA VHH BispecificAntibody (Bi-sdAb) (BIVHH-032)

Recombinant Anti-CD3 x Anti-PSMA Bispecific Antibody (Bi-sdAb) is designed to be expressed as a VHH from anti-CD3 antibody variable domains fused with a VHH from an anti-PSMA antibody variable domains. It contains a His-tag at the C/N terminus for affinity purification. The BsAb exits as monomer in reducing and non-reducing conditions. This BsAb can retarget T cells to tumor cells. It is designed for the research of Prostate cancer therapy.

Datasheet INQUIRY

Specifications

Targets

CD3 & PSMA

Type

Bi-sdAb

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Prostate cancer

Targets

Target 1

CD3

Gene ID

916

UniProt ID

P07766

Alternative Names

CD3 (Cluster of differentiation 3), originally known as T3, is one of the first groups of human T lymphocyte surface antigens recognized by monoclonal antibodies. It has been reported that antibodies against CD3 could either stimulate T cells to divide or inhibit the progress of effector functions according to the conditions used. It plays an important role in T cell and the CD3 T-cell co-receptor helps to activate the cytotoxic T-Cell and T helper cells. The CD3 molecule is composed of a protein complex and consists of four distinct chains. The complex of mammals contains a CD3γ chain, a CD3δ chain, and two CD3ε chains. All these chains associate with T-cell receptor and the ζ-chain to generate an activation signal in T lymphocytes.

Target 2

PSMA

Gene ID

2346

UniProt ID

Q04609

Alternative Names

PSM; FGCP; FOLH; GCP2; PSMA; mGCP; GCPII; NAALAD1; NAALA; FOLH1; folate hydrolase 1; NAALAdase; Glutamate carboxypeptidase 2

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Anti-CD3 VHH x Anti-PSMA VHH BispecificAntibody (Bi-sdAb) (CAT#: BIVHH-032)

Specifications

Targets

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