Name: Recombinant Anti-CD3 x Anti-PSMA VHH BispecificAntibody (Bibody)
SKU: BIBD-387
Rating: 5 (1 reviews)

Recombinant Anti-CD3 x Anti-PSMA Bispecific Antibody (Bibody) is a Fab-VHH format that uses heterodimeric Fab as a scaffold, and a VHH region linked to one of its heavy (Fd) or light (L) chain. The VHH of the anti-PSMA specificity is fused to the anti-CD3 heavy or light chain of the Fab. This BsAb can retarget T cells to tumor cells. It is designed for the research of Prostate cancer therapy.

Datasheet INQUIRY

Specifications

Targets

CD3 & PSMA

Type

Bibody

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Prostate cancer

Host Animal 1

Mouse

Host Animal 2

llama

Targets

Target 1

CD3

Gene ID

916

UniProt ID

P07766

Alternative Names

CD3 (Cluster of differentiation 3), originally known as T3, is one of the first groups of human T lymphocyte surface antigens recognized by monoclonal antibodies. It has been reported that antibodies against CD3 could either stimulate T cells to divide or inhibit the progress of effector functions according to the conditions used. It plays an important role in T cell and the CD3 T-cell co-receptor helps to activate the cytotoxic T-Cell and T helper cells. The CD3 molecule is composed of a protein complex and consists of four distinct chains. The complex of mammals contains a CD3γ chain, a CD3δ chain, and two CD3ε chains. All these chains associate with T-cell receptor and the ζ-chain to generate an activation signal in T lymphocytes.

Target 2

PSMA

Gene ID

2346

UniProt ID

Q04609

Alternative Names

PSM; FGCP; FOLH; GCP2; PSMA; mGCP; GCPII; NAALAD1; NAALA; FOLH1; folate hydrolase 1; NAALAdase; Glutamate carboxypeptidase 2

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Anti-CD3 x Anti-PSMA VHH BispecificAntibody (Bibody) (CAT#: BIBD-387)

Specifications

Targets

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