Recombinant Anti-CD3 x Anti-TFRC Bispecific Antibody (Diabody-CH3) (BSDBC-104)

Recombinant Anti-CD3 x Anti-TFRC Bispecific Antibody (Diabody-CH3) is a fusion protein of two diabodies connected together by a CH3 region. In a diabody, the two scFvs with short linkers are from anti-CD3 and anti-TFRC antibodies. The VH and VL domains form an inter-chain pairing. The diabody with different specificities is fused to each of the CH3 chains, which results in 2+2 antigen-binding valency and extends the half-life of this BsAb. This BsAb can retarget T cells to tumor cells. It is designed for the research of Erythroleukemia; Lymphoma therapy.

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Specifications

Targets

CD3 & TFRC

Type

Constant Domain-extended Bispecific Fragments

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Erythroleukemia; Lymphoma

Targets

Target 1

CD3

Gene ID

916

UniProt ID

P07766

Alternative Names

CD3; CD3E; CD3e molecule; Cluster of differentiation 3; CD3e molecule, epsilon (CD3-TCR complex); T3E; TCRE; IMD18; T-cell surface glycoprotein CD3 epsilon chain; CD3-epsilon; T-cell surface antigen T3/Leu-4 epsilon chain; CD3e antigen, epsilon polypeptide (TiT3 complex); T-cell antigen receptor complex, epsilon subunit of T3

Target 2

TFRC

Gene ID

7037

UniProt ID

P02786

Alternative Names

TFRC; transferrin receptor; T9; TR; TFR; p90; CD71; TFR1; TRFR; transferrin receptor protein 1; transferrin receptor (p90, CD71)

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Anti-CD3 x Anti-TFRC Bispecific Antibody (Diabody-CH3) (CAT#: BSDBC-104)

Specifications

Targets

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