Recombinant Anti-CD3 x Anti-TFRC Bispecific Antibody (Tandem scFv-Fc) (BSFVF-H280)

Recombinant Anti-CD3 x Anti-TFRC Bispecific Antibody (Tandem scFv-Fc) is designed to be expressed as a homodimer, which has 2+2 antigen-binding valency. This format consists of one Fc region and two tandem scFv fragments, in which the anti-CD3/TFRC tandem scFv is fused to the Fc domain. The engineered fragment format is used to extend the half-life. This BsAb can retarget T cells to tumor cells. It is designed for the research of Erythroleukemia; Lymphoma therapy.

Datasheet

Specifications

Targets

CD3 & TFRC

Type

Constant Domain-extended Bispecific Fragments

Species Reactivity

Human

Target 1

CD3

Host Animal 1

Human

Target 2

TFRC

Host Animal 2

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Erythroleukemia; Lymphoma

Targets

Target 1

CD3

Gene ID

916

UniProt ID

P07766

Alternative Names

CD3; CD3E; CD3e molecule; Cluster of differentiation 3; CD3e molecule, epsilon (CD3-TCR complex); T3E; TCRE; IMD18; T-cell surface glycoprotein CD3 epsilon chain; CD3-epsilon; T-cell surface antigen T3/Leu-4 epsilon chain; CD3e antigen, epsilon polypeptide (TiT3 complex); T-cell antigen receptor complex, epsilon subunit of T3

Target 2

TFRC

Gene ID

7037

UniProt ID

P02786

Alternative Names

TFRC; transferrin receptor; T9; TR; TFR; p90; CD71; TFR1; TRFR; transferrin receptor protein 1; transferrin receptor (p90, CD71)

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