Recombinant Human Anti-CD3 x Human Anti-TPBG Bispecific Antibody (F(ab')2-scFv2) (BABFV-H282)

Recombinant Anti-CD3 x Anti-TPBG Bispecific Antibody (F(ab')2-scFv2) is designed to be expressed as two chains combined via a hinge region. The scFv of the anti-CD3 specificity is fused to the C terminus of the anti-TPBG Fab fragment, or vice versa. This format comprises four binding sites (two same scFv regions and two same Fab fragments), two for each antigen. This BsAb can retarget T cells to tumor cells. It is designed for the research of Renal cell cancer (RCC); Non-small lung cancer therapy.

Datasheet INQUIRY

Specifications

Targets

CD3 & TPBG

Type

Fab-Fc Fusion Proteins

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Renal cell cancer (RCC); Non-small lung cancer

Targets

Target 1

CD3

Gene ID

916

UniProt ID

P07766

Alternative Names

CD3; CD3E; CD3e molecule; Cluster of differentiation 3; CD3e molecule, epsilon (CD3-TCR complex); T3E; TCRE; IMD18; T-cell surface glycoprotein CD3 epsilon chain; CD3-epsilon; T-cell surface antigen T3/Leu-4 epsilon chain; CD3e antigen, epsilon polypeptide (TiT3 complex); T-cell antigen receptor complex, epsilon subunit of T3

Target 2

TPBG

Gene ID

7162

UniProt ID

Q13641

Alternative Names

5T4; M6P1; 5T4AG; WAIF1; trophoblast glycoprotein; TPBG

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Human Anti-CD3 x Human Anti-TPBG Bispecific Antibody (F(ab')2-scFv2) (CAT#: BABFV-H282)

Specifications

Targets

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