Name: Recombinant Anti-CD3 x Anti-TROP2 Bispecific Antibody (scFv-Fc-scFv)
SKU: BSTF-107
Rating: 5 (1 reviews)

Recombinant Anti-CD3 x Anti-TROP2 Bispecific Antibody (scFv-Fc-scFv) is designed to be expressed as one chain, then assembled to a homodimer of bivalent scFv fragments and the Fc region of IgG. The anti-CD3 scFv is fused to the N-terminus of Fc via a hinge region while another anti-TROP2 scFv is linked to the C-terminus of Fc. This scFv-Fc-scFv format has 2+2 antigen-binding valency by employing different scFv fragments. This BsAb can retarget T cells to tumor cells. It is designed for the research of Pancreatic cancer; Breast cancer; Gastrointestinal cancer; Cancers therapy.

Datasheet INQUIRY

Specifications

Targets

CD3 & TROP2

Type

scFv-Fc-scFv

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Pancreatic cancer; Breast cancer; Gastrointestinal cancer; Cancers

Host Animal 1

Mouse

Host Animal 2

Mouse

Targets

Target 1

CD3

Gene ID

916

UniProt ID

P07766

Alternative Names

CD3; CD3E; CD3e molecule; Cluster of differentiation 3; CD3e molecule, epsilon (CD3-TCR complex); T3E; TCRE; IMD18; T-cell surface glycoprotein CD3 epsilon chain; CD3-epsilon; T-cell surface antigen T3/Leu-4 epsilon chain; CD3e antigen, epsilon polypeptide (TiT3 complex); T-cell antigen receptor complex, epsilon subunit of T3

Target 2

TROP2

Gene ID

4070

UniProt ID

P09758

Alternative Names

TACSTD2; tumor-associated calcium signal transducer 2; EGP1; GP50; M1S1; EGP-1; Trop-2; TROP2; GA7331; GA733-1; epithelial glycoprotein-1; cell surface glycoprotein TROP2; cell surface glycoprotein Trop-2; pancreatic carcinoma marker protein GA7331; pancreatic carcinoma marker protein GA733-1; gastrointestinal tumor-associated antigen GA7331; membrane component chromosome 1 surface marker 1; membrane component, chromosome 1, surface marker 1; 40kD glycoprotein, identified by monoclonal antibody GA733

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Anti-CD3 x Anti-TROP2 Bispecific Antibody (scFv-Fc-scFv) (CAT#: BSTF-107)

Specifications

Targets

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