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Recombinant Human Anti-CD3 x Human Anti-VEGFR2 Bispecific Antibody (Tandem scFv-Fc)  (CAT#: BSFVF-H285)

Recombinant Anti-CD3 x Anti-VEGFR2 Bispecific Antibody (Tandem scFv-Fc) is designed to be expressed as a homodimer, which has 2+2 antigen-binding valency. This format consists of one Fc region and two tandem scFv fragments, in which the anti-CD3/VEGFR2 tandem scFv is fused to the Fc domain. The engineered fragment format is used to extend the half-life. This BsAb can retarget T cells to tumor cells. It is designed for the research of Colorectal cancer (CRC); Non-small cell lung cancer (NSCLC); Glioblastoma therapy.
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Specifications

Targets
CD3 & VEGFR2
Type
Constant Domain-extended Bispecific Fragments
Species Reactivity
Human
Application
FuncS; Promising therapeutic agent
Related Disease
Colorectal cancer (CRC); Non-small cell lung cancer (NSCLC); Glioblastoma

Targets

Target 1
CD3
Gene ID
UniProt ID
Alternative Names
CD3; CD3E; CD3e molecule; Cluster of differentiation 3; CD3e molecule, epsilon (CD3-TCR complex); T3E; TCRE; IMD18; T-cell surface glycoprotein CD3 epsilon chain; CD3-epsilon; T-cell surface antigen T3/Leu-4 epsilon chain; CD3e antigen, epsilon polypeptide (TiT3 complex); T-cell antigen receptor complex, epsilon subunit of T3
Target 2
VEGFR2
Gene ID
UniProt ID
Alternative Names
FLK1; CD309; VEGFR; VEGFR2; Vascular endothelial growth factor receptor 2; Kinase insert domain receptor; Fetal liver kinase 1; Kinase insert domain receptor, a type III receptor; KDR
Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.
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