Recombinant Anti-CD317 x Anti-CD16 Bispecific Antibody (Minibody) (MiniB-111)

Recombinant Anti-CD317 x Anti-CD16 Bispecific Antibody (Minibody) is designed to be expressed as the anti-CD317 scFv fused to N-terminus of Knob-CH3 domain and the anti-CD16 scFv to the Hole-CH3 domain, or vice versa. The CH3 domains are further stabilized by C-terminal disulfide bonds. This BsAb can retarget NK cells to tumor cells. It is designed for the research of Immune diseases therapy.

Datasheet

Specifications

Targets

CD317 & CD16

Type

Minibody

Species Reactivity

Human

Target 1

CD317

Host Animal 1

Mouse

Target 2

CD16

Host Animal 2

Mouse

Application

FuncS; Promising therapeutic agent

Related Disease

Multiple myeloma (MM)

Targets

Target 1

CD317

Gene ID

684

UniProt ID

A0A024R7H5

Alternative Names

CD317; TETHERIN; BST2; bone marrow stromal cell antigen 2; Cluster of differentiation 317

Target 2

CD16

Gene ID

2214

UniProt ID

M9MML0

Alternative Names

FCGR3A; Fc fragment of IgG, low affinity IIIa, receptor (CD16a); CD16; FCG3; CD16A; FCGR3; IGFR3; IMD20; FCR-10; FCRIII; FCGRIII; FCRIIIA; low affinity immunoglobulin gamma Fc region receptor III-A; FcγRIII; FcgammaRIIIA; CD16a antigen; fc-gamma RIII; Fc-gamma RIIIa; Fc-gamma RIII-alpha; igG Fc receptor III-2; Fc gamma receptor III-A; Fc-gamma receptor IIIb (CD16); neutrophil-specific antigen NA; Fc-gamma receptor III-2 (CD 16); immunoglobulin G Fc receptor III; Fc fragment of IgG, low affinity III, receptor for (CD16)

Our services and products are only for lab research, not for any diagnostic or therapeutic use.

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USA
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-381-2994
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