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Recombinant Human Anti-CD317 x Human Anti-CD16 Bispecific Antibody (scFv-Fc)  (BSCFV-H287)

Recombinant Anti-CD317 x Anti-CD16 Bispecific Antibody (scFv-Fc) is formed by fusing two different scFv fragments to the hinge and Fc regions, in which the Fc region are engineered by KIH. Two of scFv moiety has the antibody variable domain of either anti-CD317 specificity or anti-CD16 specificity, which produces bivalent IgG-like molecules with desired characteristics of intact antibodies. This BsAb can retarget NK cells to tumor cells. It is designed for the research of Multiple myeloma (MM) therapy.

Specifications

Targets
CD317 & CD16
Type
scFv-based Bispecific Fragments
Species Reactivity
Human
Target 1
CD317
Host Animal 1
Mouse
Target 2
CD16
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
Multiple myeloma (MM)

Targets

Target 1
CD317
Gene ID
UniProt ID
Alternative Names
CD317; TETHERIN; BST2; bone marrow stromal cell antigen 2; Cluster of differentiation 317
Target 2
CD16
Gene ID
UniProt ID
Alternative Names
FCGR3A; Fc fragment of IgG, low affinity IIIa, receptor (CD16a); CD16; FCG3; CD16A; FCGR3; IGFR3; IMD20; FCR-10; FCRIII; FCGRIII; FCRIIIA; low affinity immunoglobulin gamma Fc region receptor III-A; FcγRIII; FcgammaRIIIA; CD16a antigen; fc-gamma RIII; Fc-gamma RIIIa; Fc-gamma RIII-alpha; igG Fc receptor III-2; Fc gamma receptor III-A; Fc-gamma receptor IIIb (CD16); neutrophil-specific antigen NA; Fc-gamma receptor III-2 (CD 16); immunoglobulin G Fc receptor III; Fc fragment of IgG, low affinity III, receptor for (CD16)

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