Home > Products > CD317 & CD16 > Recombinant Anti-CD317 x Anti-CD16 Bispecific Antibody (scFv-IgG)

Recombinant Anti-CD317 x Anti-CD16 Bispecific Antibody (scFv-IgG)  (BSSG-111)

Recombinant Anti-CD317 x Anti-CD16 Bispecific Antibody (scFv-IgG) is formed by an IgG and two scFv fragments. The scFvs from an anti-CD317 antibody variable domain are respectively connected to the N terminus of the anti-CD16 IgG heavy chains or light chains to form scFv-(H)IgG or scFv-(L)IgG. It is a type of appended IgGs and has 2+2 antigen-binding valency. This BsAb can retarget NK cells to tumor cells. It is designed for the research of Multiple myeloma (MM) therapy.

Specifications
Targets
CD317 & CD16
Type
Appended IgGs
Species Reactivity
Human
Target 1
CD317
Host Animal 1
Mouse
Target 2
CD16
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
Multiple myeloma (MM)
Targets
Target 1
CD317
Gene ID
UniProt ID
Alternative Names
CD317; TETHERIN; BST2; bone marrow stromal cell antigen 2; Cluster of differentiation 317
Target 2
CD16
Gene ID
UniProt ID
Alternative Names
FCGR3A; Fc fragment of IgG, low affinity IIIa, receptor (CD16a); CD16; FCG3; CD16A; FCGR3; IGFR3; IMD20; FCR-10; FCRIII; FCGRIII; FCRIIIA; low affinity immunoglobulin gamma Fc region receptor III-A; FcγRIII; FcgammaRIIIA; CD16a antigen; fc-gamma RIII; Fc-gamma RIIIa; Fc-gamma RIII-alpha; igG Fc receptor III-2; Fc gamma receptor III-A; Fc-gamma receptor IIIb (CD16); neutrophil-specific antigen NA; Fc-gamma receptor III-2 (CD 16); immunoglobulin G Fc receptor III; Fc fragment of IgG, low affinity III, receptor for (CD16)
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