Recombinant Anti-CD32B x Anti-CD79B Bispecific Antibody (VHH-IgG) is formed by an IgG and two VHH fragments. The VHHs from an anti-CD79B antibody variable domain are respectively connected to the N terminus of the anti-CD32B IgG heavy chains or light chains to form VHH-(H)IgG or VHH-(L)IgG. It is a type of appended IgGs and has 2+2 antigen-binding valency. This BsAb can regulate B-cell modulation. It is designed for the research of Immune diseases therapy.