Home > Products > CD33 & CD64 > Recombinant Human Anti-CD33 x Human Anti-CD64 Bispecific Antibody (Fab-scFv-Fc)

Recombinant Human Anti-CD33 x Human Anti-CD64 Bispecific Antibody (Fab-scFv-Fc)  (FABVC-H291)

Recombinant Anti-CD33 x Anti-CD64 Bispecific Antibody (Fab-scFv-Fc) requires expression of three polypeptide chains, encoding two heavy chains (Fc-containing chains) and one light chain, respectively. The Fab of anti-CD33 antibody variable domain is fused to the Fc-knob domain with a hinge region and the same as the scFv of anti-CD64 to the Fc-hole domain, or vice versa. The Fab-Fc and scFv-Fc fragments can be paired via the interaction of the Fc regions. This BsAb can retarget neutrophils cells to tumor cells. It is designed for the research of Acute myeloid leukemia (AML); Ulcerative Colitis (UC); Myelodysplastic syndromes (MDS); Gastric cancer therapy.

Specifications

Targets
CD33 & CD64
Type
Fab-Fc Fusion Proteins
Species Reactivity
Human
Target 1
CD33
Host Animal 1
Human
Target 2
CD64
Host Animal 2
Human
Application
FuncS; Promising therapeutic agent
Related Disease
Acute myeloid leukemia (AML); Ulcerative Colitis (UC); Myelodysplastic syndromes (MDS); Gastric cancer

Targets

Target 1
CD33
Gene ID
UniProt ID
Alternative Names
CD33; CD33 molecule; Cluster of differentiation 33; p67; SIGLEC3; SIGLEC-3; myeloid cell surface antigen CD33; gp67; CD33 antigen (gp67); sialic acid binding Ig-like lectin 3; sialic acid-binding Ig-like lectin 3
Target 2
CD64
Gene ID
UniProt ID
Alternative Names
FCGR1A; Fc fragment of IgG receptor Ia; CD64; FCRI; CD64A; IGFR1; Cluster of Differentiation 64; FcγRI; FCGR1B; FCGR1C; immunoglobulin G Fc receptor high affinity I; Fc gamma RI

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