Recombinant Anti-CD33 x Anti-DENV Bispecific Antibody (scFv-IgG) is formed by an IgG and two scFv fragments. The scFvs from an anti-CD33 antibody variable domain are respectively connected to the N terminus of the anti-DENV IgG heavy chains or light chains to form scFv-(H)IgG or scFv-(L)IgG. It is a type of appended IgGs and has 2+2 antigen-binding valency. This BsAb is designed for the research of antibody-dependent enhancement (ADE) and dengue virus infection.
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