Home > Products > CD37 & CD64 > Recombinant Anti-CD37 x Anti-CD64 Bispecific Antibody (Fab-scFv-Fc)

Recombinant Anti-CD37 x Anti-CD64 Bispecific Antibody (Fab-scFv-Fc)  (FABVC-117)

Recombinant Anti-CD37 x Anti-CD64 Bispecific Antibody (Fab-scFv-Fc) requires expression of three polypeptide chains, encoding two heavy chains (Fc-containing chains) and one light chain, respectively. The Fab of anti-CD37 antibody variable domain is fused to the Fc-knob domain with a hinge region and the same as the scFv of anti-CD64 to the Fc-hole domain, or vice versa. The Fab-Fc and scFv-Fc fragments can be paired via the interaction of the Fc regions. This BsAb can retarget neutrophils cells to tumor cells. It is designed for the research of Non-Hodgkin's lymphoma (NHL); Diffuse large B cell lymphoma (DLBCL); Chronic lymphocytic leukemia (CLL) therapy.

Specifications
Targets
CD37 & CD64
Type
Fab-Fc Fusion Proteins
Species Reactivity
Human
Target 1
CD37
Host Animal 1
Mouse
Target 2
CD64
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
Non-Hodgkin's lymphoma (NHL); Diffuse large B cell lymphoma (DLBCL); Chronic lymphocytic leukemia (CLL)
Targets
Target 1
CD37
Gene ID
UniProt ID
Alternative Names
CD37; CD37 molecule; GP52-40; TSPAN26; leukocyte antigen CD37; tspan-26; tetraspanin-26; leukocyte surface antigen CD37; cell differentiation antigen 37
Target 2
CD64
Gene ID
UniProt ID
Alternative Names
FCGR1A; Fc fragment of IgG receptor Ia; CD64; FCRI; CD64A; IGFR1; Cluster of Differentiation 64; FcγRI; FCGR1B; FCGR1C; immunoglobulin G Fc receptor high affinity I; Fc gamma RI

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