Recombinant Anti-CD37 x Anti-CD64 Bispecific Antibody (Minibody) is designed to be expressed as the anti-CD37 scFv fused to N-terminus of Knob-CH3 domain and the anti-CD64 scFv to the Hole-CH3 domain, or vice versa. The CH3 domains are further stabilized by C-terminal disulfide bonds. This BsAb can retarget neutrophils cells to tumor cells. It is designed for the research of Non-Hodgkin's lymphoma (NHL); Diffuse large B cell lymphoma (DLBCL); Chronic lymphocytic leukemia (CLL) therapy.
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