Recombinant Anti-CD37 x Anti-CD64 Bispecific Antibody (scFv-CH3) contains two chains. The anti-CD37 scFv is fused to the Knob-CH3 domain via a hinge region and the same as the anti-CD64 scFv to the Hole-CH3 domain, or vice versa. The KIH CH3 domains can facilitate to form a heterodimer and this bivalent binding leads to improvement in avidity. This BsAb can retarget neutrophils cells to tumor cells. It is designed for the research of Non-Hodgkin's lymphoma (NHL); Diffuse large B cell lymphoma (DLBCL); Chronic lymphocytic leukemia (CLL) therapy.