Home > Products > CD38 & CD59 > Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (F(ab')2-scFv2)

Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (F(ab')2-scFv2)  (BABFV-H294)

Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (F(ab')2-scFv2) is designed to be expressed as two chains combined via a hinge region. The scFv of the anti-CD38 specificity is fused to the C terminus of the anti-CD59 Fab fragment, or vice versa. This format comprises four binding sites (two same scFv regions and two same Fab fragments), two for each antigen. This BsAb can recruit complement to tumor cells. It is designed for the research of Multiple myeloma (MM); Hematologic malignancies therapy.

Specifications
Targets
CD38 & CD59
Type
Fab-Fc Fusion Proteins
Species Reactivity
Human
Target 1
CD38
Host Animal 1
Human
Target 2
CD59
Host Animal 2
Human
Application
FuncS; Promising therapeutic agent
Related Disease
Multiple myeloma (MM); Hematologic malignancies
Targets
Target 1
CD38
Gene ID
UniProt ID
Alternative Names
CD38; Cluster of differentiation 38; CD38 molecule; ADPRC1; ADPRC 1; Cyclic ADP ribose hydrolase
Target 2
CD59
Gene ID
UniProt ID
Alternative Names
CD59; CD59 molecule, complement regulatory protein; 1F5; EJ16; EJ30; EL32; G344; MIN1; MIN2; MIN3; MIRL; HRF20; MACIF; MEM43; MIC11; MSK21; 16.3A5; HRF-20; MAC-IP; p18-20; CD59 glycoprotein; protectin; 1F5 antigen; MEM43 antigen; Ly-6-like protein; T cell-activating protein; human leukocyte antigen MIC11; lymphocytic antigen CD59/MEM43; 20 kDa homologous restriction factor; membrane inhibitor of reactive lysis; membrane attack complex inhibition factor; membrane attack complex (MAC) inhibition factor; surface anitgen recognized by monoclonal antibody 16.3A5; CD59 antigen p18-20 (antigen identified by monoclonal antibodies 16.3A5, EJ16, EJ30, EL32 and G344)

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