Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (Single-chain Diabody) (SCDB-H292)

Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (Single-chain Diabody) is designed to be expressed as one polypeptide chain with four variable domains from two parental antibodies. The middle linker is long enough to form scFv dimers between the two diabody chains. This BsAb can recruit complement to tumor cells. It is designed for the research of Multiple myeloma (MM); Hematologic malignancies therapy.

Datasheet

Specifications

Targets

CD38 & CD59

Type

Single-chain Diabody

Species Reactivity

Human

Target 1

CD38

Host Animal 1

Human

Target 2

CD59

Host Animal 2

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Multiple myeloma (MM); Hematologic malignancies

Targets

Target 1

CD38

Gene ID

952

UniProt ID

P28907

Alternative Names

CD38; Cluster of differentiation 38; CD38 molecule; ADPRC1; ADPRC 1; Cyclic ADP ribose hydrolase

Target 2

CD59

Gene ID

966

UniProt ID

P13987

Alternative Names

CD59; CD59 molecule, complement regulatory protein; 1F5; EJ16; EJ30; EL32; G344; MIN1; MIN2; MIN3; MIRL; HRF20; MACIF; MEM43; MIC11; MSK21; 16.3A5; HRF-20; MAC-IP; p18-20; CD59 glycoprotein; protectin; 1F5 antigen; MEM43 antigen; Ly-6-like protein; T cell-activating protein; human leukocyte antigen MIC11; lymphocytic antigen CD59/MEM43; 20 kDa homologous restriction factor; membrane inhibitor of reactive lysis; membrane attack complex inhibition factor; membrane attack complex (MAC) inhibition factor; surface anitgen recognized by monoclonal antibody 16.3A5; CD59 antigen p18-20 (antigen identified by monoclonal antibodies 16.3A5, EJ16, EJ30, EL32 and G344)

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