Recombinant Anti-CD44 x Anti-CR3 Bispecific Antibody (F(ab')2-scFv2) (BABFV-121)

Recombinant Anti-CD44 x Anti-CR3 Bispecific Antibody (F(ab')2-scFv2) is designed to be expressed as two chains combined via a hinge region. The scFv of the anti-CD44 specificity is fused to the C terminus of the anti-CR3 Fab fragment, or vice versa. This format comprises four binding sites (two same scFv regions and two same Fab fragments), two for each antigen. This BsAb can recruit macrophages to tumor cells. It is designed for the research of Glioblastoma; Squamous cancer therapy.

Datasheet INQUIRY

Specifications

Targets

CD44 & CR3

Type

Fab-Fc Fusion Proteins

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Glioblastoma; Squamous cancer

Targets

Target 1

CD44

Gene ID

960

UniProt ID

P16070

Alternative Names

CD44; CD44 antigen; ECMRIII; Extracellular matrix receptor III; HCAM; Homing cell adhesion molecule; Pgp-1; phagocytic glycoprotein-1; HUTCH-1; Ly-24; Pgp-1; HERMES; AU023126; AW121933; AW146109

Target 2

CR3

Gene ID

719

UniProt ID

Q16581

Alternative Names

C3AR1; complement C3a receptor 1; AZ3B; C3AR; HNFAG09; CR3; Complement receptor type 3; CD11b/CD18; Mac-1; Macrophage antigen 1; αmβ2

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Anti-CD44 x Anti-CR3 Bispecific Antibody (F(ab')2-scFv2) (CAT#: BABFV-121)

Specifications

Targets

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