Home > Products > CD44 & CR3 > Recombinant Anti-CD44 x Anti-CR3 Bispecific Antibody (Fab-scFv-Fc)

Recombinant Anti-CD44 x Anti-CR3 Bispecific Antibody (Fab-scFv-Fc)  (FABVC-121)

Recombinant Anti-CD44 x Anti-CR3 Bispecific Antibody (Fab-scFv-Fc) requires expression of three polypeptide chains, encoding two heavy chains (Fc-containing chains) and one light chain, respectively. The Fab of anti-CD44 antibody variable domain is fused to the Fc-knob domain with a hinge region and the same as the scFv of anti-CR3 to the Fc-hole domain, or vice versa. The Fab-Fc and scFv-Fc fragments can be paired via the interaction of the Fc regions. This BsAb can recruit macrophages to tumor cells. It is designed for the research of Glioblastoma; Squamous cancer therapy.

Specifications
Targets
CD44 & CR3
Type
Fab-Fc Fusion Proteins
Species Reactivity
Human
Target 1
CD44
Host Animal 1
Mouse
Target 2
CR3
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
Glioblastoma; Squamous cancer
Targets
Target 1
CD44
Gene ID
UniProt ID
Alternative Names
CD44; CD44 antigen; ECMRIII; Extracellular matrix receptor III; HCAM; Homing cell adhesion molecule; Pgp-1; phagocytic glycoprotein-1; HUTCH-1; Ly-24; Pgp-1; HERMES; AU023126; AW121933; AW146109
Target 2
CR3
Gene ID
UniProt ID
Alternative Names
C3AR1; complement C3a receptor 1; AZ3B; C3AR; HNFAG09; CR3; Complement receptor type 3; CD11b/CD18; Mac-1; Macrophage antigen 1; αmβ2

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