Home > Products > CD44 & CR3 > Recombinant Anti-CD44 x Anti-CR3 Bispecific Antibody (scFv-Fc)

Recombinant Anti-CD44 x Anti-CR3 Bispecific Antibody (scFv-Fc)  (BSCFV-121)

Recombinant Anti-CD44 x Anti-CR3 Bispecific Antibody (scFv-Fc) is formed by fusing two different scFv fragments to the hinge and Fc regions, in which the Fc region are engineered by KIH. Two of scFv moiety has the antibody variable domain of either anti-CD44 specificity or anti-CR3 specificity, which produces bivalent IgG-like molecules with desired characteristics of intact antibodies. This BsAb can recruit macrophages to tumor cells. It is designed for the research of Glioblastoma; Squamous cancer therapy.

Specifications
Targets
CD44 & CR3
Type
scFv-based Bispecific Fragments
Species Reactivity
Human
Target 1
CD44
Host Animal 1
Mouse
Target 2
CR3
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
Glioblastoma; Squamous cancer
Targets
Target 1
CD44
Gene ID
UniProt ID
Alternative Names
CD44; CD44 antigen; ECMRIII; Extracellular matrix receptor III; HCAM; Homing cell adhesion molecule; Pgp-1; phagocytic glycoprotein-1; HUTCH-1; Ly-24; Pgp-1; HERMES; AU023126; AW121933; AW146109
Target 2
CR3
Gene ID
UniProt ID
Alternative Names
C3AR1; complement C3a receptor 1; AZ3B; C3AR; HNFAG09; CR3; Complement receptor type 3; CD11b/CD18; Mac-1; Macrophage antigen 1; αmβ2

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