Home > Products > CD44 & CR3 > Recombinant Anti-CD44 x Anti-CR3 Bispecific Antibody (Tandem scFv-Fc)

Recombinant Anti-CD44 x Anti-CR3 Bispecific Antibody (Tandem scFv-Fc)  (BSFVF-H295)

Recombinant Anti-CD44 x Anti-CR3 Bispecific Antibody (Tandem scFv-Fc) is designed to be expressed as a homodimer, which has 2+2 antigen-binding valency. This format consists of one Fc region and two tandem scFv fragments, in which the anti-CD44/CR3 tandem scFv is fused to the Fc domain. The engineered fragment format is used to extend the half-life. This BsAb can recruit macrophages to tumor cells. It is designed for the research of Glioblastoma; Squamous cancer therapy.

Specifications
Targets
CD44 & CR3
Type
Constant Domain-extended Bispecific Fragments
Species Reactivity
Human
Target 1
CD44
Host Animal 1
Human
Target 2
CR3
Host Animal 2
Human
Application
FuncS; Promising therapeutic agent
Related Disease
Glioblastoma; Squamous cancer
Targets
Target 1
CD44
Gene ID
UniProt ID
Alternative Names
CD44; CD44 antigen; ECMRIII; Extracellular matrix receptor III; HCAM; Homing cell adhesion molecule; Pgp-1; phagocytic glycoprotein-1; HUTCH-1; Ly-24; Pgp-1; HERMES; AU023126; AW121933; AW146109
Target 2
CR3
Gene ID
UniProt ID
Alternative Names
C3AR1; complement C3a receptor 1; AZ3B; C3AR; HNFAG09; CR3; Complement receptor type 3; CD11b/CD18; Mac-1; Macrophage antigen 1; αmβ2

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