Recombinant Anti-CD45 x Anti-Myosin Bispecific Antibody (scFv-CH3) contains two chains. The anti-CD45 scFv is fused to the Knob-CH3 domain via a hinge region and the same as the anti-Myosin scFv to the Hole-CH3 domain, or vice versa. The KIH CH3 domains can facilitate to form a heterodimer and this bivalent binding leads to improvement in avidity. This BsAb can recruit stem cells to infarcted myocardium. It is designed for the research of Myocardial infarction therapy.
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