Recombinant Anti-CD55 x Anti-HLA-A Bispecific Antibody (Fab-scFv-Fc) (FABVC-H298)

Recombinant Anti-CD55 x Anti-HLA-A Bispecific Antibody (Fab-scFv-Fc) requires expression of three polypeptide chains, encoding two heavy chains (Fc-containing chains) and one light chain, respectively. The Fab of anti-CD55 antibody variable domain is fused to the Fc-knob domain with a hinge region and the same as the scFv of anti-HLA-A to the Fc-hole domain, or vice versa. The Fab-Fc and scFv-Fc fragments can be paired via the interaction of the Fc regions. This BsAb can recruit complements to tumor cells. It is designed for the research of Renal cell cancer (RCC); Solid tumors therapy.

Datasheet

Specifications

Targets

CD55 & HLA-A

Type

Fab-Fc Fusion Proteins

Species Reactivity

Human

Target 1

CD55

Host Animal 1

Human

Target 2

HLA-A

Host Animal 2

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Renal cell cancer (RCC); Solid tumors

Targets

Target 1

CD55

Gene ID

1604

UniProt ID

P08174

Alternative Names

CD55; CD55 molecule, decay accelerating factor for complement (Cromer blood group); CR; TC; DAF; CROM; complement decay-accelerating factor; CD55 antigen

Target 2

HLA-A

Gene ID

3105

UniProt ID

P30443

Alternative Names

HLA-A; major histocompatibility complex, class I, A; HLAA; HLA class I histocompatibility antigen, A-1 alpha chain; antigen presenting molecule; leukocyte antigen class I-A; MHC class I antigen HLA-A heavy chain

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