Home > Products > CD64 & EGFR > Recombinant Anti-CD64 x Anti-EGFR Bispecific Antibody (VHH-Fc-VHH)

Recombinant Anti-CD64 x Anti-EGFR Bispecific Antibody (VHH-Fc-VHH)  (HCAB-036)

Recombinant Anti-CD64 x Anti-EGFR Bispecific Antibody (VHH-Fc-VHH, Tetravalent HCAb) is a fusion protein of two diabodies connected together by an Fc region. In a diabody, the two VHHs with short linkers are from anti-CD64 and anti-EGFR antibodies. The VH and VL domains form an inter-chain pairing. The diabody with different specificities is fused to the Fc fragment, which results in 2+2 antigen-binding valency and exerts Fc-mediated functions or just extends the half-life. This BsAb can retarget neutrophils cells to tumor cells. It is designed for the research of Head and neck cancer; Colorectal cancer (CRC); Glioblastoma multiforme (GBM); Squamous cancer; Glioblastoma; Medulloblastoma; Non-small cell lung cancer (NSCLC); Renal cell cancer (RCC); Solid tumors therapy.

Specifications
Targets
CD64 & EGFR
Type
Constant Domain-extended Bispecific Fragments
Species Reactivity
Human
Target 1
CD64
Host Animal 1
llama
Target 2
EGFR
Host Animal 2
llama
Application
FuncS; Promising therapeutic agent
Related Disease
Neuroblastoma; Osteosarcoma; Melanoma; Solid tumors
Targets
Target 1
CD64
Gene ID
UniProt ID
Alternative Names
FCGR1A; Fc fragment of IgG receptor Ia; CD64; FCRI; CD64A; IGFR1; Cluster of Differentiation 64; FcγRI; FCGR1B; FCGR1C; immunoglobulin G Fc receptor high affinity I; Fc gamma RI
Target 2
EGFR
Alternative Names
Ganglioside GD2; GD2; Ganglioside; Disialoganglioside GD2
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