Home > Products > CD64 & HIV-1 gp41 > Recombinant Anti-CD64 x Anti-HIV-1 gp41 Bispecific Antibody (Diabody-CH3)

Recombinant Anti-CD64 x Anti-HIV-1 gp41 Bispecific Antibody (Diabody-CH3)  (BSDBC-127)

Recombinant Anti-CD64 x Anti-HIV-1 gp41 Bispecific Antibody (Diabody-CH3) is a fusion protein of two diabodies connected together by a CH3 region. In a diabody, the two scFvs with short linkers are from anti-CD64 and anti-HIV-1 gp41 antibodies. The VH and VL domains form an inter-chain pairing. The diabody with different specificities is fused to each of the CH3 chains, which results in 2+2 antigen-binding valency and extends the half-life of this BsAb. This BsAb can retarget neutrophils cells to tumor cells. It is designed for the research of HIV-1 infection, AIDS therapy.

Specifications

Targets
CD64 & HIV-1 gp41
Type
Constant Domain-extended Bispecific Fragments
Species Reactivity
Human
Target 1
CD64
Host Animal 1
Mouse
Target 2
HIV-1 gp41
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
HIV-1 infection, AIDS

Targets

Target 1
CD64
Gene ID
UniProt ID
Alternative Names
FCGR1A; Fc fragment of IgG receptor Ia; CD64; FCRI; CD64A; IGFR1; Cluster of Differentiation 64; FcγRI; FCGR1B; FCGR1C; immunoglobulin G Fc receptor high affinity I; Fc gamma RI
Target 2
HIV-1 gp41
Gene ID
UniProt ID
Alternative Names
ENV; gp160; Envelope glycoprotein 120; envelope glycoprotein; Envelope surface glycoprotein gp160, precursor; hypothetical protein; Envelope surface glycoprotein gp120; Envelope transmembrane domain; human immunodeficiency virus type 1; human immunodeficiency virus type 1 gp120; human immunodeficiency virus type 1 glycoprotein 120; gp41; GP41; glycoprotein 41

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