Recombinant Anti-CD64 x Anti-malaria antigen Bispecific Antibody (IgG-Fv) is formed by an Immunoglobulin G (IgG) and a fragment variable Fv region, in which the Fc of IgG is engineered by KIH. The Fv region of an anti-CD64 antibody variable domain is fused to the C terminal of an IgG of anti-malaria antigen antibody, or vice versa. The format retains desired characteristics of intact antibodies. This BsAb can retarget NK cells to genus plasmodium. It is designed for the research of Malaria therapy.